As we age, many of us begin to lose muscle and this can begin as early as in our thirties. This decline can bring with it a loss of strength, stability, balance and eventually can result in frailty in our older years. Science has demonstrated that increasing our protein intake, especially when combined with resistance exercise and supplementing our diet with specific nutrients can prevent this loss of muscle.
Anti-aging product of the year MEND Regenerate is formulated to combat muscle loss, fight free radical damage and help the body to manage inflammation. It is such a unique and effective formula that MEND Regenerate is now taken as a primary nutrition product by many professional sports teams and elite athletes.
Protein is considered a key nutrient in older age. Dietary protein provides amino acids that are needed for the synthesis of muscle protein, and importantly, absorbed amino acids have a stimulatory effect on muscle protein synthesis after feeding.
Recommended protein intakes may, therefore, need to be raised in older people in order to maintain nitrogen balance and to protect them from sarcopenic muscle loss.
Studies have confirmed that consuming a blend of proteins can provide a prolonged delivery of amino acids to the skeletal muscles, making it optimal for consumption for individuals concerned with addressing age related muscle loss.
Our protein complex provides a scientific combination of three high quality proteins selected specifically to aid digestion, increase protein synthesis and to prevent protein breakdown.
Data supports the ability of dietary protein to acutely stimulate muscle protein synthesis in aging individuals and that moderately increasing daily protein intake beyond the recommended daily allowance may enhance muscle protein anabolism and provide a means of reducing the progressive loss of muscle mass with age.
A study published in The Journal of Nutrition demonstrates the benefits of consuming a protein blend for muscle protein synthesis after exercise. The correct blend of proteins can provide complementary amino acid profiles and different digestion rates (amino acid release profiles). The result provides fast absorption combined with a prolonged delivery of amino acids to muscles and extended muscle protein synthesis when subjects consumed a blend when compared to a single source of protein alone.
Branched chain amino acids, also known as BCAAs, serve as the building blocks of muscle protein. Muscle is made up of protein, and protein is made up of individual amino acids added together through a process called protein synthesis.
Branched-chain amino acids or BCAAs are a combination of essential amino acids which include L-leucine, L-isoleucine and L-valine. They are not produced in the human body so must be consumed from dietary sources.
A study conducted at the University of Texas Medical Branch at Galveston concluded the important role of leucine in the formulation of any amino acid/protein supplement for reversing a weakened response of muscle protein synthesis to nutritional supplementation in the elderly.
HMB is a metabolite of the essential amino acid Leucine and is synthesized in the human body. It plays a part in protein synthesis. MEND contains 1.5 grams of HMB per one scoop serving.
Numerous studies have found increases in lean muscle mass and strength in the elderly and clinical populations when using HMB. Our research section contains papers as well as a link to PubMed which can be used to look up the studies on HMB. Please read “International Society of Sports Medicine Postion on HBM.”
Glutamine is the most common amino acid found in your muscles and over 61% of skeletal muscle is Glutamine. Glutamine consists of 19% nitrogen, making it the primary transporter of nitrogen into your muscle cells. Research indicates trauma and injury can lower the levels of Glutamine to the point of deficiency.
According to NYU Lagone Medical Center “Heavy exercise, infection, surgery, and trauma can deplete the body’s glutamine reserves, particularly in muscle cells. The fact that glutamine does so many good things in the body has led people to research glutamine supplements as a treatment for various conditions, including preventing the infections that often follow endurance exercise, reducing symptoms of overtraining syndrome, improving nutrition in critical illness, alleviating allergies, and treating digestive problems. Please read Nutrition in Clinical Practice’s “Clinical applications of Glutamine”.
Aminogen, a patented ingredient, is a blend of digestive enzymes developed specifically to be added to high quality protein supplements to increase protein absorption and amino acid levels.
The digestive proteases in Aminogen help break down ingested protein into individual amino acids which are then absorbed by the body to maintain and repair damaged cells, muscle tissue, and organs.
With traditional protein supplements, much of the protein goes through the digestive system without being broken down into amino acids. The digestive tract cannot absorb protein if it is not first broken down into individual amino acids.
Aminogen was engineered to combat this exact problem as it assists the body in breaking down protein into individual amino acids and allows the body to use more of the protein in our protein supplement.
The Laboratory of Nutrition and Nutritional Biochemistry, University of Yaounde I, Cameroon, conducted a clinical study on Aminogen. This study tracked the increases in protein absorption, nitrogen retention, and blood CRP reduction in subjects who were first given a protein supplement without Aminogen, and then later given a protein supplement with Aminogen.
Two groups of healthy males were assigned a specific balanced diet during all legs of the study. Each subject was dosed with 50 grams of whey protein concentrate (WPC) following an overnight fast. Nine days later the groups were again dosed with 50 grams of WPC following an overnight fast, but this time the protein contained 2.5g of Aminogen for one group or 5g of Aminogen for the other.
The study found that almost all individual amino acid blood levels, excluding glycine, histidine, methionine, and serine, were significantly higher in the second dosing compared to the first. Nitrogen levels were also much higher and CRP levels were reduced.
The study was published in the Journal of the International Society of Sports Nutrition.
A 2008 study published in the Journal of the International Society of Sports Nutrition found that adding Aminogen digestive enzyme system to whey protein favorably impacted three important factors related to aging metabolism: the product helped to triple the rate of protein absorption, increase branched‐chain amino acid absorption by 250% and increased nitrogen retention by 32%.
MCT, or medium chain triglycerides, refer to a unique form of dietary fat that imparts a wide range of positive health benefits. MCTs are generally made by processing coconut oil which is composed of capric acid, caprylic acid, and lauric acid.
Unlike most other dietary oils, MCT oil is an excellent source of energy which gets burned immediately by the liver before it even has a chance to get stored as body fat. It does not contribute to the development of cardiovascular disease and it may indirectly reduce the risk of may types of cardiovascular diseases (due to the absence of polyunsaturated fatty acids).
In addition, research has suggested that combined supplementation of MCTs (6 g), leucine-rich amino acids, and vitamin D may improve muscle strength and function in frail elderly individuals.
Age related muscle loss is often accompanied by increased levels of body fat and a reduction in metabolism. MCT’s have been shown to reduce body fat deposits while increasing basal metabolic rate.
In one 16-week study, 31 overweight patients consumed either olive oil or MCT oil in muffins. All of the subjects participated in dietitian-led weekly group weight-loss counseling sessions that stressed following a prudent diet, and encouraged healthy eating patterns. The oils accounted for roughly 12 percent of participants’ calorie prescription.
At 16 weeks, the MCT group had lost significantly more weight: an average of 7 pounds, or 3.8 percent of their baseline body weight, compared with 1.7 percent in the olive oil group…an over 200% improvement and over twice the total weight loss of the control group. The MCT group also had a 1.5 percent decrease in total fat mass as measured by CT scan, including a reduction in intra-abdominal fat.
Fructooligosaccharides (FOS) are oligosaccharides that occur naturally in plants such as onion, tomatoes, chicory, garlic, asparagus, banana, artichoke, among many others. Of these foods the Jerusalem artichoke has the highest concentrations of FOS.
FOS have a number of interesting properties and currently FOS are becoming increasingly popular due to their prebiotic effect as they have been found to stimulate the growth of nonpathogenic intestinal microflora which helps support digestion and reduce constipation.
Prebiotic’s are referred to as “friendly, beneficial” bacteria called microbiota. Microbiota produce essential nutrients such as short-chain fatty acids which help prevent overgrowth of infectious organisms, boost intestinal immunity and prevent inflammation, diarrhea and other intestinal conditions.
The gut microbiota is the population of bacteria and other microbes that live in your gut. This community is highly complex, and contains both good and bad bacteria. Having the right balance of bacteria is essential for keeping your gut healthy and protecting you from disease.
Fructooligosaccharides can help promote this balance. In fact, studies have shown that FOS can help stimulate the growth of beneficial bacteria. Increasing the amounts of these bacteria can help improve digestion, immunity and overall health.
In addition, to their prebiotic benefits, Fructooligosaccharides also increase calcium absorption in the body, an important consideration for pre- and post-menopausal women, ages 45 and older, who are losing critical bone mass that increases their risk for osteoporosis and bone fractures.
Resveratrol is a compound found naturally in foods such as grapes, nuts, red wine, some berries, and in other fruits and plants. The function of this compound in plants is to confer resistance against bacterial and fungal infection. In humans, It has been shown to have a plethora of health benefits including protection against cardiovascular disease, various cancers, type II diabetes, and also has life extending properties.
As for its beneficial cellular effects on skeletal muscle, resveratrol has been shown to alter protein catabolism and muscle function while providing resistance against oxidative stress, injury, and cell death of skeletal muscle cells.
Research findings provide evidence for the modest but potentially important benefits of resveratrol supplementation in improving skeletal muscle regeneration following a period of disuse with a subsequent recovery in aging. Resveratrol has been shown to alter metabolism, inhibit protein catabolism, improve function, and provides resistance against oxidative cellular stress, injury, and cell death of skeletal muscle cells. This is particularly relevant in the elderly population which experience preferential atrophy of type II fibers in sarcopenia.
Researchers have determined the health properties of green tea are mostly due to polyphenols, chemicals with potent antioxidant potential. In fact, the antioxidant effects of polyphenols seem to be greater than vitamin C.
Polyphenols contained in teas are classified as catechins. Green tea also contains alkaloids including caffeine, theobromine, and theophylline. They provide green tea’s stimulant effects. L-theanine, an amino acid compound found in green tea, has been studied for its calming effects on the nervous system.
Population-based studies and clinical trials have shown that green tea is beneficial to human health. Laboratory studies have also shown that green tea may help protect against loss of brain cells, bacterial and viral infections, allergies, arthritis and decreased bone mineral density, among other health concerns. A clinical trial in human volunteers has also revealed that green tea also helps improve immunity and prevents cold and flu symptoms in its participants.
Digestive enzymes aid in the absorption of nutrients and assist in the breaking down of the food you eat. This process allows the nutrition you have consumed to be used as energy, to support the building of new muscle and nerve cells, as well as protecting your blood from toxins.
Inadequate enzyme production can lead to digestive discomfort, gas, bloating, low energy and allergy-like reactions to food. The three main categories of digestive enzymes are amylase, protease and lipase. Enzymes called amylases break down starches into sugar molecules; proteases break down proteins into amino acids; and lipases break down fat into its component parts.
Our enzyme blend was designed specifically to support the digestion and enzymatic breakdown of proteins along with the other nutritional compounds found in MEND Regenerate.
Papain – A proteolytic enzyme occurring in the unripe fruit of the papaya tree, known medically as Carica papaya, that catalyzes the breakdown of proteins by hydrolysis and in medicine is utilized as an aid to protein digestion.
Bromelain – A mixture of enzymes found in pineapples (Ananas comosus) that digest protein (proteolytic), Bromelain may help reduce pain, swelling and bruising while accelerating healing from surgery and injuries. Its protein-digesting effects break up and disperse the products of inflammation, many of which are protein molecules. Researchers concluded that enzyme therapy reduced pain and accelerated healing.
Lipase – An essential enzyme for the digestion of fat, lipase is responsible for breaking down (hydrolyzing) fats into smaller components that can readily be absorbed through the intestines. Research has shown that when accompanied by other enzymes, lipase reduced overall symptoms of indigestion (including the sensation of being overly full, flatulence and bloating) while boosting the absorption of vitamins and minerals following consumption of a nutrient dense snack or meal.
Aging increases risk for digestive disorders and digestive symptoms can occur anytime throughout a person’s life. As we age, nearly one in three people in the US experience some kind of digestive problem and nearly 40 percent of older adults report at least one digestive disorder symptom per year, according to Johns Hopkins Medicine.
These digestive disturbances can range from serious medical conditions to the more popular symptoms including constipation, indigestion, gas and/or diarrhea. As we age, or if we over-restrict caloric intake, digestive irregularities, such as constipation, may stem from reduced food intake or poor diet.
The human body produces its own CoQ10, although levels decline with age and may become low if you develop a chronic disease such as cardiovascular disease, diabetes or cancer. CoQ10, which is also called ubiquinone, functions as an antioxidant and is an essential component of the energy-generating machinery in the mitochondria of all of your body’s cells. CoQ10 is absorbed from your small intestine with dietary fats and regulates osteoclast and osteoblast differentiation.
CoQ10 is needed in the mitochondria of your body’s cells to make the storage form of energy called adenosine triphosphate, or ATP. Raising a low CoQ10 level could benefit problems with energy production in tissues such as heart or muscle, and increasing your CoQ10 intake may improve your exercise capacity and endurance.
Grape seed extracts are rich in compounds called procyanidolic oligomers (PCOs) which is a powerful antioxidant and is considered to be more potent than vitamins C and E. The procyanide in grape seed extracts are water soluble bioflavonoids that benefits the body by fighting free radicals. Grape seed extracts also contains vitamin E, flavonoids, linoleic acid and resveratrol.
A study of healthy volunteers found that taking grape seed extract substantially increased blood levels of antioxidants. Antioxidants are substances that destroy free radicals, which are harmful compounds in the body that damage DNA (genetic material) and even cause cell death. Scientists believe free radicals contribute to aging, as well as the development of a number of health problems, including heart disease and cancer. Another study found that people who took grape seed extract after experiencing a sports injury had less swelling than those who took a placebo.
Creatine is proving to be one of the most promising, well-researched and safest supplements ever discovered for an exceptionally wide range of uses. It is a nutrient with a long list of potential medical, exercise enhancing, and anti-aging applications.
In literally dozens of studies, creatine has been shown to increase strength and muscle mass in young and old alike as an aid in rehabilitative strength training. Creatine has also demonstrated potential therapeutic applications in aging populations against disorders such as fatigue, frailty, muscle atrophy, age related muscle loss and other wasting syndromes.
In a study examining creatine’s effect on isometric strength and body composition, 28 healthy men and women over the age of 65 received either five grams of creatine daily or a placebo. In this random, double-blind study, both the creatine and placebo groups were put on a resistance (weight) training regimen. Fourteen weeks of training resulted in significant increases in all measurements of strength, functional tasks, and muscle fiber area in both groups.
However, the creatine group experienced significantly greater increases in fat-free muscle mass, knee extension strength, ankle strength and intramuscular creatine levels. The researchers concluded that the addition of creatine supplementation to the exercise stimulus enhanced the increase in total fat-free mass and gains in several indices of participant muscle strength.
Vitamin A is a fat soluble vitamin which is present in many foods. Two different types of vitamin A are found in the diet. Preformed vitamin A is found in animal products such as meat, fish, poultry and dairy foods. The other type, pro-vitamin A is found in plant-based foods such as fruits and vegetables. MEND contains 1250 IU of Vitamin A per one scoop serving.
According to National Institute of Health: “Vitamin A is essential for good health. It promotes growth, the immune system, reproduction, and vision. However, recent research suggests that too much vitamin A, particularly in the form of retinol, may be bad for your bones.” Please refer to the NIH Osteoporosis and Related Bone Diseases site for more information on studies and recommended intake.
B vitamins are a class of water-soluble vitamins that play important roles in cell metabolism. In general, dietary supplements containing all eight are referred to as a vitamin B complex.
These essential nutrients play many important roles in the body like help the body convert our food into fuel, which allows us to stay energized throughout the day. In addition, healthy nervous system functioning along with supporting Fat and protein metabolism are also aided by B vitamins
Below is a list of all the different ways that B complex vitamins support the human body:
B-Complex allows for supplementation of all eight vitamins simultaneously, as multiple deficiencies can overload the body with a number of illnesses and ailments. The B-Complex vitamin is a powerhouse of a vitamin combination as all of these separate vitamins work hand in hand to deliver powerful health benefits to the body. These health benefits provided by the B-complex vitamin include support of the metabolism and increase in the rate of metabolism, maintenance of healthy muscle tone and skin and enhancing the function of the nervous system and the immune system.
Vitamin C is a water soluble nutrient found in some foods. Because of the additional free radical damage typically occurring with injury, vitamin C can be consumed by the body quickly during the healing process. MEND contains 250 milligrams of Vitamin C per one scoop serving.
According to PubMed: “Clinical studies provide evidence that wound healing in subjects judged not deficient in vitamin C can be significantly accelerated with supplements of this nutrient above the recommended daily allowance (RDA).” According to another study on Vitamin C as an antioxidant: “Vitamin C in humans must be ingested for survival. Vitamin C is an electron donor, and this property accounts for all its known functions. As an electron donor, vitamin C is a potent water-soluble antioxidant in humans. Antioxidant effects of vitamin C have been demonstrated in many experiments in vitro.” According to Dr. Sinatra: Because surgery depletes your body of vitamin C, take 500–1,000 mg as part of your daily routine before surgery and 1,000 mg three times a day after surgery. Return to your usual dosage after two weeks. Numerous studies indicate that vitamin C helps prevent surgical shock and post-surgical bed sores, and that it significantly speeds healing time. It’s also necessary for the production of collagen—a basic structural protein used in wound repair.
Vitamin D is an essential vitamin which the body produces in exposure to sunlight. It can be found in few foods naturally. MEND contains 400 IU of Vitamin D per one scoop serving.
Vitamin D has become one of the most researched and prescribed vitamins. Conclusions according to one study: “This meta-analysis supports the use of vitamin D3 of 800 IU daily to reduce the incidence of osteoporotic non-vertebral, hip, and non-vertebral-non-hip fractures in elderly women. Vitamin D(3) with calcium appears to achieve benefits above those attained with calcium supplementation alone for non-vertebral and non-vertebral-non-hip fractures.”
Calcium is a chemical element which is essential for living organisms, including humans. It is found in many foods. We need to consume a certain amount of calcium to build and maintain strong bones and healthy communication between the brain and various parts of the body.
The findings of a 2013 study, published in Current Biology, shows that a flash of calcium is the body’s first response to healing damaged tissue. According to Medscape: “Calcium plus vitamin D supplements are routinely prescribed for the prevention of osteoporosis and fracture. Although a major study from 2006 questioned this practice, a new meta-analysis reaffirms the usefulness of calcium plus vitamin D in the prevention of fracture.”
Magnesium is an essential mineral for helping us to stay healthy and is required for more than 300 biochemical reactions in the body. Multiple health benefits of magnesium include transmission of nerve impulses, body temperature regulation, detoxification, energy production, and the formation of healthy bones and teeth. It also helps muscles and nerves function properly, keeps your heart rhythm steady and also supports a healthy immune system.
This essential mineral helps regulate blood sugar levels, promotes normal blood pressure and is required for producing and storing energy. It’s easy to see why many researchers say that no single dietary factor is as critical as magnesium.
Magnesium enables your body to work, effectively. As the enabler of muscle relaxation, magnesium helps prevent and alleviate many health complaints such as headaches, constipation, cramps, and more. Equally important, magnesium helps restore cellular balance as a result of the body’s stress response.
Older age is frequently characterized by sarcopenia, a loss of skeletal muscle mass and function that is a strong independent risk factor for disability and mortality. Recent data show that inadequate magnesium intake is common, especially in older persons. Because magnesium status is strictly related to muscle ATP, and because both magnesium deficiency and sarcopenia tend to be more prevalent at older ages, it was hypothesized that poor magnesium status contributes to late-life sarcopenia.
The results of the study show an independent concurrent relation between serum magnesium and muscle performance in a large cohort of community-resident older persons. A possible mechanism of this association is the effect of magnesium concentrations on mitochondrial function in muscle, which may be particularly critical in aging muscle.
One of the most vital functions of potassium is its role in stimulating cell growth, ensuring the proper growth of muscle tissues and the proper utilization of energy released during metabolism.
Potassium plays an important role in regular muscle relaxation and contraction which adds significantly to muscle strength. As a matter of fact, most of the potassium ions in the human body are located in the muscle cells, maintaining optimal muscle and nerve function, while keeping our reflexes fast by stimulating the neural connectivity of muscles and the brain!
The benefits of potassium extend to improving the health of your bones by neutralizing various acids throughout the body which retain and preserve calcium, making it inaccessible to use for bone strength and durability.
Furthermore, a study at the Linus Pauling Institute Micronutrient Information Center claims that eating fruits and vegetables that have high levels of potassium results in higher mineral density in bones, further strengthening and prolonging the life of your bones!
Potassium is a very important mineral for the proper function of all cells, tissues, and organs in the human body. Studies have shown a positive link between a diet rich in potassium and bone health, particularly among elderly women, suggesting that potassium may play a role in preventing osteoporosis. There is also some evidence that potassium supplements may cause a slight drop in blood pressure.
Selenium is an essential trace mineral that has a wide array of health benefits, including its ability to protect heart health, boost the strength of the immune system, maximize thyroid function, reduce inflammation, protect against antibodies and balance your hormones. It also is important for cognitive function, the production of prostaglandins and to support a healthy immune system.
Your body uses selenium to make enzymes called selenoproteins. There are 25 of them, and some of them — such as glutathione peroxidases — work as antioxidants, which are molecules that prevent against cell damage.
Clinical studies on the use of selenium were searched for in the PubMed electronic database. Sixteen clinical studies were identified among the 167 articles selected in the initial search. The studies were conducted worldwide including European, American and Asian countries between 1987 and 2012.. Selenium supplementation improved the general conditions of the patients while improving the quality of life and reducing the side effects of those who received radiotherapy.
Sodium is an element that the body needs to work properly. The body uses sodium to control blood pressure and blood volume.
Sodium also creates electrical impulses essential for nerve impulse transmission, muscle contraction and heartbeat regulation.
Sodium bicarbonate, unlike sodium chloride or table salt, is very alkaline which forms a buffering system that regulates the body’s ph levels. IT also neutralizes acids produced during metabolism, such as those that can cause pain in muscles during exercise.
MEND Regenerate is available from your Orthopedic Surgeon or Doctor and can be purchased directly from our website.
Yes, MEND is shipped worldwide. Please be aware of your country’s policy for importing dietary supplements and that additional taxes and tariffs may be applied by your country.
Currently available in chocolate/cocoa and vanilla. The vanilla version is NSF Sport certified to allow for use in professional sports and therefore is a little more expensive. We will be adding flavors.
MEND Regenerate contains only well-studied nutrients that are well tolerated with no known contraindications with prescription medications. It should be safe to take while on medications. It is always advisable to consult with your doctor before taking any dietary supplements.
All of the nutrients in MEND Regenerate were selected based on the science and evidence supporting their efficacy. We now have years of patient and client data and testimonials suggesting that when used in conjunction with resistance training and exercise, MEND Regenerate will provide multiple benefits.
We recommend that you blend MEND Regenerate into a smoothie to help aid absorption of nutrients. There are a number of smoothie recipes provided on our website.
Yes we are looking to partner with physicians and other healthcare providers. Please email us at firstname.lastname@example.org for more information.